摘要 |
<p>Compounds of formula (I): wherein R<1>, R<2> and R<3> are independently, hydrogen, halogen, CF3, OR<6>, NR<7> R<8>, NR<8>COR<10>, NR<8>SO2R<10> or C 1-6 alkyl optionally substituted by hydroxy, C 1-6 alkoxy or NR<7>R<8>; R<4> is NR<8>CONR<8>R<9>; and R<5> formula (Ia) is methods for their synthesis, pharmaceutical compositions comprising them and their use in medicine, in particular for the treatment of cancer.</p> |