GROUP B STREPTOCOCCAL PHAGE LYSIN

摘要

The present disclosure relates to the identification of the phage lysine from group B streptococci (GBS). The nucleic acid sequence and amino acid sequence of the GBS phage lysine is disclosed. The GBS phage lysine is a unique bifunctional protein comprising a glucosidase and an endopeptidease activity. The endopeptidease present in the GBS phage lysis has a substrate specificity that has not been previously reported. The bifunctional GBS phage lysine is effective against groups A, B, C, E and G streptococci. Also described are methods of using the GBS phage lysine for the prevention and treatment of bacterial infections.