(1H-BENZOIMIDAZOL-2-YL)-(PIPERAZINYL)-METHANONE DERIVATIVES AND RELATED COMPOUNDS AS HISTAMINE H4-RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS

摘要

(1H-Benzoimidazol-2-YL)-(Piperazinyl)-Methanone derivatives of formula (I) and related compounds as histamine H4-receptor antagonists for the treatment of inflammatory and allergic disorders (I) wherein B and B<1> are C or up to one of B and B<1> may be N; Y is O, S or NR<2>, where R<2> is H or C1-4alkyl; Z is O or S; R<8> is H and R<9> is (II), where R<10 >Is H or C1-4alkyl, or R<8> and R<9> are taken together with their N of attachment to form (III); n is 1 or 2; m is 1 or 2; n + m is 2 or 3; other substituents as defined In claim 1.