METHOD FOR PRODUCING OPTICALLY ACTIVE AMINO ALCOHOL

摘要

PROBLEM TO BE SOLVED: To provide a method for producing an optically active amino alcohol useful for the synthesis of a natural product or as an intermediate material of a medicine and an agrochemical, in a high yield and high selectivity, economically and with a good productivity.

SOLUTION: This method for producing the optically active amino alcohol expressed by formula (2) (wherein, R1is a hydrocarbon group, an aromatic heterocyclic group or an aliphatic heterocyclic ring group; R2and R3are each H, a hydrocarbon group, an acyl, an acyloxy, an alkyloxycarbonyl, an aralkyloxycarbonyl, an aryloxycarbonyl or a heterocyclic group; R4is H or a protecting group, and R1to R4may link together to form a ring; and * shows that it is an asymmetric carbon, provided that when the R2or R3is H, the carbon atom bonded with the R2or R3is not the asymmetric carbon) is provided by performing the asymmetric hydrogenation reaction of a compound expressed by formula (1) (wherein, R1to R4are the same as above; and a double bond is either cis or trans).

COPYRIGHT: (C)2004,JPO