发明名称 |
Sustained release pharmaceutical formulation for inhalation |
摘要 |
Pharmaceutical formulations and methods are provided for the sustained delivery of a pharmaceutical agent to the lungs of a patient by inhalation. The formulation includes porous microparticles which comprise a pharmaceutical agent and a matrix material, wherein upon inhalation of the formulation a therapeutically or prophylactically effective amount of the pharmaceutical agent is released from the microparticles in the lungs for at least 2 hours. Preferably, a majority of the pharmaceutical agent is released from the microparticles by 24 hours following inhalation, for example where a majority of the pharmaceutical agent is released no earlier than about 2 hours and no later than about 24 hours following inhalation. Methods for delivering a pharmaceutical agent, such as a corticosteroid, to the lungs of a patient are also provided. For example, the method includes having the patient inhale a dry powder blend comprising the present microparticles and a pharmaceutically acceptable bulking agent.
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申请公布号 |
US2004105821(A1) |
申请公布日期 |
2004.06.03 |
申请号 |
US20030675874 |
申请日期 |
2003.09.30 |
申请人 |
BERNSTEIN HOWARD;CHICKERING DONALD E.;HUANG ERIC K.;REESE SHAINA;NARASIMHAN SRIDHAR;STRAUB JULIE A. |
发明人 |
BERNSTEIN HOWARD;CHICKERING DONALD E.;HUANG ERIC K.;REESE SHAINA;NARASIMHAN SRIDHAR;STRAUB JULIE A. |
分类号 |
A61K9/00;A61K9/16;A61K31/00;A61K31/56;A61K31/58;(IPC1-7):A61L9/04;A61K9/14 |
主分类号 |
A61K9/00 |
代理机构 |
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