发明名称 |
BACTERIOPHAGE HAVING MODIFIED HOLIN AND USES THEREOF |
摘要 |
The present invention features composition and methods for treating a bacterial infection using therapeutic bacteriophage having a modified holin gene. The modified holin inactivates the bacterial host prior to production of bacteriophage, so that the bacteriophage infection is non-productive, e.g., few or no bacteriophage are produced as a result of infection of the bacterial host. Thus, holin-modified bacteriophage invade the bacterial host, and cause inactivation of the bacterial host prior to production of a detectable or significant number of phage. Holin-modified phage inhibit the spread of bacterial infection without production of a significant or detectable number of phage progeny. By avoiding the release of phage progeny, the potential for generation of immune responses against the phage is reduced. |
申请公布号 |
WO2004046319(A2) |
申请公布日期 |
2004.06.03 |
申请号 |
WO2003US36400 |
申请日期 |
2003.11.14 |
申请人 |
GANGAGEN, INC.;RAMACHANDRAN, JANAKIRAMAN;PADMANABHAN, SRIRAM;SRIRAM, BHARATHI |
发明人 |
RAMACHANDRAN, JANAKIRAMAN;PADMANABHAN, SRIRAM;SRIRAM, BHARATHI |
分类号 |
A61K35/76;C07K14/01;C12N7/00;C12N7/02 |
主分类号 |
A61K35/76 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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