发明名称 |
Process for producing camptothecin |
摘要 |
Problem: A large scale production of camptothecin, which is a starting compound of irinotecan hydrochloride and various camptothecin derivatives, at a low cost and with ease.Solution: A process for preparing camptothecin, characterized in that it comprises the following steps (a) and (b);(a) the step to hydrolyze 9-methoxycamptothecin or a natural material containing 9-methoxycamptothecin;(b) the step to convert 9-hydroxycamptothecin obtained in the step (a) into camptothecin by 9-O-perfluoro-lower-alkylsulfonylation or 9-O-phenyltetrazolylation, followed by hydrogenolysis.
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申请公布号 |
US6743918(B2) |
申请公布日期 |
2004.06.01 |
申请号 |
US20020239113 |
申请日期 |
2002.11.25 |
申请人 |
KABUSHIKI KAISHA YAKULT HONSHA |
发明人 |
YAEGASHI TAKASHI;OGAWA TAKANORI;SAWADA SEIGO |
分类号 |
A61K31/475;A61P35/00;C07D491/22;(IPC1-7):C07D491/12;A61K31/936 |
主分类号 |
A61K31/475 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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