ISOLATION AND STRUCTURAL ELUCIDATION OF THE HUMAN CANCER CELL GROWTH INHIBITORY COMPOUND DENOMINATED AGELAGALASTATIN

摘要

A human cancer cell line bioassay-directed investigation of the Western Pacific marine sponge agelas sp. led to isolation of a trace (7.42 x 10-6% yield) cancer cell growth inhibitor (lung NCI-H460 GI50 0.77 .mu.g/ml to ovary OVCAR-3 GI50 2.8 .mu.g/ml) designated agelagalastatin (6). Agelagalastatin is the first example of a natural produ ct containing a digalactofuranosyl unit.