ENZYMATIC PROCESS FOR THE PREPARATION OF SUBSTITUTED 2-AMINO-3-(2-AMINO- PHENYLSULFANYL)-PROPIONIC ACID

摘要

The present invention relates to a new process for the preparation compounds of formula I wherein R¹, R², R³ and n are as described in the description which process comprises reacting compounds of formula II wherein R¹, R², R³, n and R⁴ are as described in the description, with a protease in an aqueous system containing an organic co-solvent. The compound of formula I are useful for the preparation of 1,5-benzothiazepines which are useful as enzyme inhibitors, such as protease, interleukin-1beta-converting enzyme, elastase or angiotensin converting enzyme, GPCR antagonists (cholecystokinin, angiotensin II receptor).