PROCESS OF PREPARING TOLTERODINE AND ANALOGUES THERE OF AS WELL AS INTERMEDIATES PREPARED IN THE PROCESS

摘要

The invention provides a process for the enantioselective preparation of a compound of the general formula (Ia) or (Ib): wherein R1, R2 and R3 independently of each other are hydrogen, methyl, methoxy, hydroxy, hydroxymethyl, carbamoyl, sulphamoyl or halogen, and R4 and R5 independently of each other are C1-6 alkyl, or a salt thereof, which process comprises the steps of: d) converting a compound of formula (Va) or (Vb): wherein R1, R2 and R3 are as defined above, to form the corresponding enantiomerically enriched compound of formula (Ia) or (Ib); and e) optionally converting the compound of formula (Ia) or (Ib) to a salt thereof.