A controlled -release dosage form has a coated core with the core comprising a drug-containing composition and a water-swellable composition, each occupying separate regions within the core. The drug-containing composition comprises a low-solubility drug and a drug-entraining agent. The coating around the core is water-permeable, water-insoluble and has at least one delivery port therethrough. A variety of formulations having specific drug release profiles are disclosed.
申请公布号
HU0301242(A2)
申请公布日期
2004.05.28
申请号
HU20030001242
申请日期
2000.12.20
申请人
PFIZER PRODUCTS INC., GROTON
发明人
APPEL, LEAH ELIZABETH;BEYERINCK, RONALD ARTHUR;CHIDLAW, MARK BRIAN;CURATOLO, WILLIAM JOHN;FRIESEN, DWAYNE THOMAS;SMITH, KELLY LINCOLN;THOMBRE, AVINASH GOVIND