| 摘要 |
A process for the preparation of 4- (4-pyridinyl) benzoic acid, or a salt thereof, comprising: reacting a mixture of 4-carboxybenzeneboronic acid, optionally in the form of a salt, 4-bromopyridine, also optionally in the form of a salt, and a base, all parts being substantially dissolved in a solvent, in the presence of a catalyst of formula R3P)4Pd, wherein R is selected from an aromatic ring, a heteroaromatic ring, a cycloalkyl group or an aliphatic group, the catalyst may be water soluble such as palladium acetate or tetrakis(triphenylphosphine)palladium(0) is disclosed.
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