Excitatory amino acid receptor modulators

摘要

Compounds of the formula (I) in which: R<1 >is (CH2)nY; n is 1 or 2; Y is NHSO2R<2 >or X<1>-W-X<2>-R<3>; X<1 >is O or NH; W is C=O, C=S, C=NH, or SO2; X<2 >is O or NH, provided that X<1 >and X<2 >are not both O; R<2 >is C1-10 alkyl; C2-10 alkenyl; C2-10 alkynyl; aryl; aryl-C1-10 alkyl; aryl-C2-10 alkenyl; aryl-C2-10alkynyl; C3-8 cycloalkyl or C3-8-cycloalkyl-C1-10 alkyl; and R<3 >is hydrogen, C1-10alkyl; C2-10 alkenyl; C2-10 alkynyl; aryl; aryl-C1-10 alkyl; aryl-C2-10 alkenyl; aryl-C2-10 alkynyl; C3-8 cycloalkyl; or C3-8-cycloalkyl-C1-10 alkyl; or a salt or ester thereof, modulate metabotropic glutamate receptor function and are useful in treating disorders of the central nervous system.