Methods for controlling the lysis of coagulated blood with apolipoprotein e4 theno type

摘要

Methods for inhibiting the lysis of coagulated blood comprise administering to blood a lysis-inhibiting amount of apolipoprotein E4 (Apo E4) or a therapeutic derivative thereof. Methods for reducing the risk of excessive blood clot lysis comprise administering the blood a lysis-inhibiting amount of Apo E4 or a therapeutic derivative thereof. Additional methods for inhibiting the lysis of coagulated blood comprise administering to an individual's blood a specific level of a lysis-inhibiting amount of Apo E4 wherein the specific level is based upon the apolipoprotein phenotype of the individual. Further methods for reducing the risk of excessive blood clot lysis comprise administering to an individual's blood a specific level of a lysis-inhibiting amount of Apo E4, wherein the specific level is based upon the apolipoprotein phenotype of the individual. Additional methods for enhancing the lysis of coagulated blood comprise administering to blood containing a clot lysis agent an Apo E peptide fragment.