DIAGNOSIS OF SEPSIS OR SIRS USING BIOMARKER PROFILES

摘要

The early prediction or diagnosis of sepsis advantageously allows for clinic al intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplishe d by comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population that develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsi s allows a clinician to diagnose the onset of sepsis or SIRS from a bodily flu id isolated from the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms of sepsis.