发明名称 |
HUMAN SCHWANNOMA CELL LINE |
摘要 |
In a preferred embodiment, the present invention relates to a Schwannoma cell line derived from a Schwann tumor in a patient with Neurofibromatosis type 2 (NF2) and immortalized with HPV E6-E7 genes. The cell line has a unique splice site mutation of the NF2 gene. The immortalized cell line is non-tumorigenic but has altered growth properties such as higher proliferation rate and independence of Schwann cell growth factors. Methods of using this unique cell line for pharmacologic screening are disclosed. |
申请公布号 |
WO03073996(A3) |
申请公布日期 |
2004.05.27 |
申请号 |
WO2003US06314 |
申请日期 |
2003.03.03 |
申请人 |
HOUSE EAR INSTITUTE;HUNG, GENE;LI, XIANKUI |
发明人 |
HUNG, GENE;LI, XIANKUI |
分类号 |
C12N5/02;C12N5/09;G01N33/50 |
主分类号 |
C12N5/02 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|