QUINOLINE DERIVATIVES WHICH ENHANCE COGNITION VIA THE GABA-A RECEPTOR

摘要

The present invention provides a compound of formula (I), or a pharmaceutically acceptable salt thereof: wherein X<1> represents hydrogen, halogen, C1-6 alkyl, trifluoromethyl or C1-6 alkoxy; X<2> represents hydrogen or halogen; Y represents a chemical bond, an oxygen atom, or a -NH- linkage; Z represents an optionally substituted aryl or heteroaryl group; R<1> represents hydrogen, hydrocarbon, a heterocyclic group, halogen, cyano, trifluoromethyl, nitro, -OR<a>, -SR<a>, -SOR<a>, -SO2R<a>, -SO2NR<a>R<b>, NR<a>R<b>, -NR<a>COR<b>, -NR<a>CO2R<b>, -COR<a>, -CO2R<a>, -CONR<a>R<b> or -CR<a=>NOR<b>; and R<a> and R<b> independently represent hydrogen, hydrocarbon or a heterocyclic group;a pharmaceutical composition comprising it, its use in therapy; use of it for manufacturing a medicament; and methods using it to treat or prevent anxiety, convulsions or cognitive disorders.