SIGNALING PROTEINS PARTICIPATING IN IMMUNOPOTENTIATION BY VIRUS-ORIGIN DOUBLE-STRANDED RNA AND ENDOTOXIN AND GENES THEREOF

摘要

It is intended to provide proteins having an interferon-induced signaling activity and participating in immunopotentiation by a virus-origin double-stranded RNA and an endotoxin, genes thereof, and method of using the same. Namely, DNA's (SEQ ID NOS:1 and 3) encoding proteins having an interferon-induced signaling activity and participating in immunopotentiation by a virus-origin double-stranded RNA and an endotoxin, and proteins (SEQ ID NOS: 2 and 4) having an interferon-induced signaling activity expressed by these DNA's. Mutant DNA's and mutant proteins derived from the above DNA's and proteins; antibodies specifically binding to the above proteins; nonhuman animals lacking the above genes on chromosome; and a method of judging immunopotentiation ability of cells and a method of screening an interferon-induced signaling substance using such an antibody, e nonhuman animal and a gene probe.