POLYSACCHARIDE VACCINE FOR STAPHYLOCOCCAL INFECTIONS

摘要

The invention relates to compositions of a deacetylated poly N-acetylated glucosamine (dPNAG) of Staphylococci. The dPNAG may be isolated from natural sources or synthesized de novo.The invention also relates to the use of dPNA G as a vaccine for inducing active immunity to infections caused by Staphylococcus aureus, S. epidermidis, other related coagulase-negative or coagulase-positive Staphylococci, and other organisms carrying the ica (intracellular adhesion) locus. The invention further provides methods of us e for antibodies directed to dPNAG, particularly for inducing passive immunity to the same class of infections.