MODIFIED OLIGONUCLEOTIDES FOR USE IN RNA INTERFERENCE,申请号WO2003US35086-传众专利搜索

发明名称	MODIFIED OLIGONUCLEOTIDES FOR USE IN RNA INTERFERENCE
摘要	The present invention provides modified oligonucleotides for use in the RNA interference pathway of gene modulation. At least one nucleoside has a 2'-modification other than hydroxyl that gives an RNA like 3'-endo sugar conformation. The modified oligonucleotides are also provided having a 5'-phosphate group.
申请公布号	WO2004044139(A2)	申请公布日期	2004.05.27
申请号	WO2003US35086	申请日期	2003.11.04
申请人	ISIS PARMACEUTICALS, INC.;BAKER, BRENDA, F.;ELDRUP, ANNE, B.;MANOHARAN, MUTHIAH;BHAT, BALKRISHEN;GRIFFEY, RICHARD;SWAYZE, ERIC, E.	发明人	BAKER, BRENDA, F.;ELDRUP, ANNE, B.;MANOHARAN, MUTHIAH;BHAT, BALKRISHEN;GRIFFEY, RICHARD;SWAYZE, ERIC, E.
分类号	C07H21/00;C07H21/04;C12N15/113;C12Q1/68	主分类号	C07H21/00
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