METHODS AND COMPOSITIONS FOR MODULATING P53 TRANSCRIPTION FACTOR
摘要
This invention provides novel p53 modulatory polypeptides. The invention also provides methods for screening modulators of p53. The methods comprise first screening test agents for modulators of a p53-modulatory polypeptide and then further screening the identified modulating agents for modulators of p53. The invention further provides methods and pharmaceutical compositions for modulating p53 bioactivities in a cell and for treating diseases and conditions mediated by abnormal cellular proliferation.
申请公布号
WO2004043371(A2)
申请公布日期
2004.05.27
申请号
WO2003US35420
申请日期
2003.11.07
申请人
IRM LLC;THE SCRIPPS RESEARCH INSTITUTE;HUANG, QIHONG;CHANDA, SUMIT;HOGENESCH, JOHN, B.;CALDWELL, JEREMY, S.
发明人
HUANG, QIHONG;CHANDA, SUMIT;HOGENESCH, JOHN, B.;CALDWELL, JEREMY, S.