| 发明名称 |
3-SUBSTITUTED-6-ARYL PYRIDINES AS LIGANDS OF C5A RECEPTORS |
| 摘要 |
3-substituted-6-aryl pyridines of Formula (I) are provided: Formula (I) wherein R1, R2, R3, R8, R9, A and Ar are defined herein. Such compounds are ligands of C5a receptors. Preferred compounds of Formula (I) bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agoni st activity at C5a receptors. The present invention also relates to pharmaceutical compositions comprising such compounds, and to the use of suc h compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. In addition, the present invention provides labeled 3- substituted-6-aryl pyridines, which are useful as probes for the localizatio n of C5a receptors.
|
| 申请公布号 |
CA2504941(A1) |
申请公布日期 |
2004.05.27 |
| 申请号 |
CA20032504941 |
申请日期 |
2003.11.07 |
| 申请人 |
NEUROGEN CORPORATION |
发明人 |
GUO, QIN;HRNCIAR, PETER;GUO, ZIHONG;LIU, NIAN;CHENARD, BERTRAND L.;HUTCHISON, ALAN;MAYNARD, GEORGE;LEE, KYUNGAE;YUAN, JUN |
| 分类号 |
A61P9/00;A61P29/00;C07B61/00;C07D213/30;C07D213/38;C07D213/42;C07D213/64;C07D213/65;C07D213/68;C07D213/71;C07D213/74;C07D213/81;C07D213/84;C07D213/89;C07D401/04;C07D401/06;C07D401/12;C07D405/12;C07D405/14;C07D413/04;C07D413/06;C07D413/12;C07D413/14;C07D417/14;C07D471/04;(IPC1-7):C07D401/04;C07D417/06;C07D401/14;C07D213/40;A61K31/443;A61K31/444 |
主分类号 |
A61P9/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
