BIOLOGICAL CARRIERS FOR THE DELIVERY OF PROTEINS OR PEPTIDES
摘要
<p>Methods for delivering potentially therapeutic or prophylactic protein and peptide agents to mammalian cells are provided. The agents are delivered by mutant trypanosomatid protozoa that have been genetically manipulated to code for such protein or peptide agents. The mutant protozoa additionally lack certain enzymes within the heme biosynthetic pathway, making the mutants susceptible to porphyria and eventual lysis.</p>
申请公布号
WO2004044184(A1)
申请公布日期
2004.05.27
申请号
WO2003US35747
申请日期
2003.11.11
申请人
FINCH UNIVERSITY OF HEALTH SCIENCES
发明人
CHANG, KWANG-POO;SASSA, SHIGERU;SAH, JEROME, F.;ITO, HIROYI;KOLLI, BALA, KRISHNA;PETERSON, DANIEL, A.