Recombinant anaerobic bacterial compositions that under anaerobic conditions present in a solid tumor and produce an enzyme capable of catalyzing the conversion of a prodrug to its cytotoxic product in situ are described. Methods of treating tumors using the composition are also described.
申请公布号
WO03102169(B1)
申请公布日期
2004.05.27
申请号
WO2003US17291
申请日期
2003.05.30
申请人
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY;HEALTH PROTECTION AGENCY
发明人
BROWN, JOHN, M.;LIU, SHIE-CHAU;GIACCIA, AMATO, J.;MINTON, NIGEL, P.