发明名称 |
Estrogen receptor modulators |
摘要 |
Isoxazole estrogen receptor agonist and antagonist compounds having unexpected and surprising activity in modulating estrogen receptor activity are described. In addition, methods and compositions for treating or preventing estrogen receptor-mediated disorders are disclosed. The compounds, methods, and compositions of the invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.
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申请公布号 |
US2004102498(A1) |
申请公布日期 |
2004.05.27 |
申请号 |
US20030713621 |
申请日期 |
2003.11.13 |
申请人 |
HUEBNER VERENA D.;LIN XIAODONG;JAMES IAN;CHEN LIYA;DESAI MANOJ;MOORE JENNIFER C.;KRYWULT BEATA;NAVARATNAM THAYALAN;SINGH RAJINDER;TRAINOR ROB;WANG LIANG |
发明人 |
HUEBNER VERENA D.;LIN XIAODONG;JAMES IAN;CHEN LIYA;DESAI MANOJ;MOORE JENNIFER C.;KRYWULT BEATA;NAVARATNAM THAYALAN;SINGH RAJINDER;TRAINOR ROB;WANG LIANG |
分类号 |
A61K31/42;A61K31/422;A61K31/423;A61K31/424;A61K31/4433;A61K31/4439;A61K31/454;A61K31/4745;A61P5/30;A61P19/10;A61P25/28;A61P43/00;C07D261/08;C07D261/10;C07D261/18;C07D261/20;C07D409/04;C07D413/04;C07D413/12;C07D498/04;(IPC1-7):C07D261/02 |
主分类号 |
A61K31/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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