COMPUTER SYSTEM AND METHODS FOR PRODUCING MORPHOGEN ANALOGS OF HUMAN TDF-1

摘要

The invention disclosed herein provides methods and compositions for the computer-assisted design of morphogen analogs. Practice of the invention is enabled by the use of at least a portion of the atomic co-ordinates defining the three-dimensional structure of human transformation and differentiation factor-1 (hTDF-1) as a starting point in the design of the morphogen analogs. In addition, the invention provides methods for producing morphogen analogs of interest, and methods for testing whether the resulting analogs mimic or agonize human TDF-1-like biological activity. The invention also provides a family of morphogen analogs produced by such methods.