发明名称 |
Viruses targeted to hypoxic cells and tissues |
摘要 |
The present invention relates to compositions comprising a novel recombinant virus which replicates selectively in cells or tissues that are hypoxic or have an activated HIF pathway. The novel compositions of the invention comprise a recombinant virus genetically engineered to have an hypoxia-responsive element, or a multiplicity of such elements, operably linked to a promoter which is operably linked to a gene or genes which regulate or modulate replication of the virus or encode a therapeutic molecule. The invention also includes constructs useful for screening for agents which interact with proteins or genes in the hypoxia-inducible pathway.
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申请公布号 |
US2004101825(A1) |
申请公布日期 |
2004.05.27 |
申请号 |
US20030363453 |
申请日期 |
2003.07.10 |
申请人 |
VAN MEIR ERWIN G.;NICHOLSON AINSLEY C.;POST DAWN E. |
发明人 |
VAN MEIR ERWIN G.;NICHOLSON AINSLEY C.;POST DAWN E. |
分类号 |
A61K48/00;C12N15/861;(IPC1-7):C12Q1/70;C12N7/00;C12N15/867 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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