| 摘要 |
A compound of formula (I) or pharmaceutically acceptable salts and solvates thereof. R1 and R2 are independently H or C1-3alkyl, m is 0-3; X<1 >is NH, NCH3, O, S; R<3>, R<4 >and R<5 >are independently H, CH3, CF3, OCH3, allyl or halogen; X<2 >is (CR<10>R<11>)n wherein n is 1 or 2; R<10 >and R<11 >independently represent H, fluorine or C1-16alkyl; R<26 >and R<27 >are independently H, C1-3 alkyl or R<26 >and R<27 >together with the carbon atom to which they are bonded form a 3-5 membered cycloalklyl ring. R<6 >and R<7 >independently represent H, fluorine or C1-16alkyl; R<9 >is C1-6alkyl or CF3; One of Y and Z is N, the other is S or O; Each R<8 >independently represents CF3, OCH3, CH3 or halogen; y is O, 1, 2, 3, 4, 5. Use of a compound of formula (I) for the manufacture of a medicament for the prevention or treatment of a hPPAR mediated disease or condition, such as dyslipidemia, syndrome X, heart failure, hypercholesteremia, cardiovascular disease, type II diabetes mellitus, type 1 diabetes, insulin resistance hyperlipidemia, obesity, anorexia bulimia, inflammation and anorexia nervosa.
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