New modified vaccinia virus Ankara (MVA) comprising in the viral genome an expression cassette comprising the cowpox ATI promoter or its derivative and a coding sequence, useful for the treatment and/or prophylaxis of viral infections

摘要

A recombinant modified vaccinia virus Ankara (MVA) comprising in the viral genome an expression cassette comprising the cowpox ATI promoter or its derivative and a coding sequence, where the expression of the coding sequence is regulated by the promoter, is new. - Independent claims are included for the following: - (1) a vaccine or pharmaceutical composition comprising the recombinant MVA; - (2) a method for introducing a coding sequence into target ells by infecting the target cells with the recombinant MVA; - (3) a method for producing a peptide, protein and/or virus by infecting a host with the virus cited above; cultivating the infected host cell under suitable conditions; and - (4) isolating and/or enriching the peptide, protein and/or virus produced by the host cell; - (5) a method for affecting, preferably inducing an immunological response in a living animal body including a human by administering the virus or the composition/vaccine to the animal or human to be treated; - (6) a cell containing the virus; and - (7) method for producing a recombinant MVA by inserting an expression cassette into the genome of MVA. - ACTIVITY - Virucide. - No biological data given. - MECHANISM OF ACTION - Vaccine.