发明名称 |
METHODS FOR THE SYNTHESIS OF AMINES SUCH AS EPHEDRINE AND INTERMEDIATES |
摘要 |
<p>A method for the preparation of a compound of formula (VI): in which R<SUB>2 </SUB>is an optionally substituted C1-C6 alkyl; R<SUB>4 </SUB>is H, OH, an optionally substituted C1-C6 alkyl or an optionally substituted C1-C6 alkoxy; R<SUB>5 </SUB>is an optionally substituted aryl, an optionally substituted aralkyl, or an optionally substituted alkyl; and R<SUB>6 </SUB>is H or an optionally substituted C1-C6 alkyl; the method including the step of subjecting a ketone of formula (V) in which R<SUB>2</SUB>, R<SUB>4 </SUB>and R<SUB>5 </SUB>are as defined above, to reductive amination with an amine of formula R<SUB>3</SUB>NH<SUB>2 </SUB>in which R<SUB>3 </SUB>is an optionally substituted alkyl, and a reductant to form the compound of formula (VI), wherein the reaction is conducted in the presence of a supercritical fluid or a liquefied gas.</p> |
申请公布号 |
EP1421055(A1) |
申请公布日期 |
2004.05.26 |
申请号 |
EP20020764370 |
申请日期 |
2002.08.26 |
申请人 |
POLYCHIP PHARMACEUTICALS PTY. LTD.;VICTORIA UNIVERSITY OF TECHNOLOGY |
发明人 |
SMALLRIDGE, ANDREW, JOHN;TREWHELLA, MAURICE, ARTHUR;WILKINSON, KYLIE, ANNE |
分类号 |
C12P13/02;C07B61/00;C07C209/24;C07C209/26;C07C211/17;C07C211/27;C07C211/29;C07C213/02;C07C215/30;C07C215/34;C07C215/60;C07C249/02;C12R1/865;(IPC1-7):C07C209/24 |
主分类号 |
C12P13/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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