Crystal structure of dipeptidyl peptidase IV

摘要

The present invention relates to crystal structure information obtained from crystals of the dipeptidyl-peptidase DPP-IV, to methods of preparing such crystals, and to their use for the identification and/or design of inhibitors of DPP-IV activity. A further subject matter of the invention are methods for the identification and/or design of inhibitor compounds of DPP-IV activity, the inhibitor compounds of DPP-IV activity identified by these methods and their use in pharmaceutical compositions for the treatment and/or prevention of diseases comprising diabetes types I and II, IGT, obesity and cancer.