发明名称 |
High molecular weight and low molecular weight fractions of von Willebrand factor |
摘要 |
Sepn. of von Willebrand factor (vWF) into high and low mol. wt. fractions comprises binding vWF to an affinity column and carrying out elution at different salt concns. Also new are: (1) low mol. wt. fraction (A) of vWF, consisting mainly of dimers and tetramers and (2) high mol. wt. fraction (B) of at ≥ 50 (pref. ≥ 60)% increased activity (per mu g. of protein) in platelet aggregation compared with the physiological mixt. of both forms. |
申请公布号 |
EP0705846(B1) |
申请公布日期 |
2004.05.26 |
申请号 |
EP19950115442 |
申请日期 |
1995.09.29 |
申请人 |
BAXTER AKTIENGESELLSCHAFT |
发明人 |
FISCHER, BERNHARD, DR.;MITTERER, ARTUR, DR.;DORNER, FRIEDRICH, PROF. DR. |
分类号 |
A61K38/43;A61K38/00;A61P7/04;C07K1/22;C07K14/745;C07K14/755 |
主分类号 |
A61K38/43 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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