| 摘要 |
This invention is directed to compounds of the formula:wherein j is 0 or 1; k is 0 or 1; m is 0 or 1; n is 0 or 1; W is -O-; -S(=O)t-, where t is 0, 1, or 2; or -N(R<3>)-; where R<3 >is -H, -(C1-C3) alkyl, -OR<12>, phenyl, or benzyl; R<C >and R<D >have the same meaning as R<A >and R<B>, except that at least one of R<C >and R<D >must be -H; and the other variables are defined as set forth in the specification. The invention is also directed to pharmaceutical compositions comprising the above compounds and to methods of treating a subject suffering from a disease, disorder or condition mediated by the PDE4 isozyme, the method comprising administering a therapeutically effective amount of a compound as described above. The invention is particularly directed to methods of treating inflammatory, respiratory and allergic diseases and conditions, especially asthma; chronic obstructive pulmonary disease (COPD) including chronic bronchitis, emphysema, and bronchiectasis; chronic rhinitis; and chronic sinusitis. |
