CANCER THERAPY DETERMINATION

摘要

A method of determining a suitable chemotherapeutic agent for an individual comprises the steps of assaying a biological sample from the individual for BRCA1 activity. When the activity is greater than or equal to a normal level, an antimicrotubule chemotherapeutic agent is recommended. When the activity is below a normal level, a DNA damaging chemotherapeutic agent is recommended. BRCA1 activity is determined by assaying for BRCA1 mutation, BRCA1 expression levels, or both. A kit for carrying out the method of the invention is also disclosed.