发明名称 |
ANTIGEN UPTAKE RECEPTOR FOR CANDIDA ALBICANS ON DENDRITIC CELLS |
摘要 |
Dendritic cells (DC) that express the type II C-type lectin DC-SIGN (CD209) are located in the submucosa of tissues, where they mediate HIV-1 entry. Interestingly, the pathogen Candida albicans, the major cause of hospital-acquired fungal infections, is found at similar sites. Here it is demonstrated that DC-SIGN is able to bind Candida albicans both in DC-SIGN transfected cell lines and in human monocyte derived DC. Moreover, in immature DC, DC-SIGN is able to internalize Candida in specific DC-SIGN enriched vesicles, distinct from those containing the mannose receptor (MR; CD206), which is another Candida receptor on DC. Together, these results demonstrate that C. albicans has two major receptors on human monocyte derived DC, these receptors being DC-SIGN and MR. Targeting of DC-SIGN offers novel opportunities to combat chronic forms of candidiasis. |
申请公布号 |
WO2004026326(A3) |
申请公布日期 |
2004.05.21 |
申请号 |
WO2003IB04661 |
申请日期 |
2003.09.19 |
申请人 |
STICHTING KATHOLIEKE UNIVERSITEIT;FIGDOR, CARL, GUSTAV;TORENSMA, RUURD |
发明人 |
FIGDOR, CARL, GUSTAV;TORENSMA, RUURD |
分类号 |
A61K31/702;A61K38/17;A61P31/00;C07K16/28 |
主分类号 |
A61K31/702 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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