发明名称 |
METHODS AND COMPOSITIONS FOR THE GENERATION OF HUMANIZED MICE |
摘要 |
The invention provides methods and compositions for generating non-human transgenic animals that are humanized at one or more gene sequences. According to the methods of the invention, a DNA construct containing a human DNA sequence flanked by sequences from the non-human animal is generated by recombination in a bacterial cell, for example, in E. coli. The DNA construct that is produced can then be introduced into a non-human embryogenic stem cell where it can recombine with the genomic DNA of the non-human animal.
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申请公布号 |
WO2004022738(A8) |
申请公布日期 |
2004.05.21 |
申请号 |
WO2003US28485 |
申请日期 |
2003.09.09 |
申请人 |
CALIFORNIA INSTITUTE OF TECHNOLOGY;SHIZUYA, HIROAKI |
发明人 |
SHIZUYA, HIROAKI |
分类号 |
A01K67/00;A01K67/027;C12N15/00;C12N15/09;C12N15/10;C12N15/63;C12N15/74;C12N15/85;C12N15/90;(IPC1-7):C12N15/00 |
主分类号 |
A01K67/00 |
代理机构 |
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代理人 |
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地址 |
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