ANTIGENIC TARGETS OF AUTOIMMUNE SENSORINEURAL HEARING LOSS (AISNHL) AND DEVELOPMENT OF TESTS FOR DIAGNOSIS AND MANAGEMENT OF AISNHL

摘要

This invention relates generally to antigens reactive with autoantibodies associated with autoimmune sensorineural hearing loss (AISNHL), and in particular relates to a novel antigen, Inner Ear Supporting Cell Antigen (IESCA) reactive with autoantibodies associated with autoimmune sensorineura l hearing loss (AISNHL), and to methods for the detecting therapeutic outcomes in treatment of AISNHL patients, and to methods of detecting genetic lesions in genes encoding for such antigens.