发明名称 TETRAHYDROPYRANYL CYCLOPENTYL BENZYLAMIDE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
摘要 The present invention is directed to compounds of the formula (I) (wherein R 1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R27, R28, R29, R30, R31, X, m, n a nd the dashed line are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.
申请公布号 CA2502174(A1) 申请公布日期 2004.05.21
申请号 CA20032502174 申请日期 2003.10.24
申请人 MERCK & CO., INC. 发明人 ZHOU, CHANGYOU;PASTERNAK, ALEXANDER;GOBLE, STEPHEN, D.;YANG, LIHU;SHANKARAN, KOTHANDARAMAN;BUTORA, GABOR;MILLS, SANDER, G.
分类号 A61K31/00;C07C237/24;C07D211/58;C07D211/96;C07D305/08;C07D307/22;C07D309/14;C07D311/00;C07D311/02;C07D311/68;C07D311/74;C07D313/04;C07D319/06;C07D333/36;C07D335/02;C07D405/04;C07D405/12;C07D409/12;C07D417/12;C07D491/04;C07D493/08;C07D498/04;(IPC1-7):C07D498/04;C07D491/02;C07D257/04;C07D491/052;C07D407/12;A61K31/165;A61K31/195;C07D277/26;A61K31/343;A61K31/351;A61K31/352;A61K31/381;A61K31/407;A61K31/41;A61K31/416;A61K31/427;A61K31/446;A61K31/453;C07D263/48;A61K31/538;C07C233/57;C07D307/93 主分类号 A61K31/00
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