PYRAZOLONAPHTHYRIDINE DERIVATIVE

摘要

A PDE IV inhibitor which is excellent in antiasthatic effect and the effect of prevention of or treatments for COPD and is highly safe. A compound represented by the general formula (1): (1) (wherein A is a phenyl, pyridyl, 1-oxypyridyl, or thienyl group optionally substituted by one or more substituents selected from the group consisting of hydroxy, halogeno, cyano, nitro, lower alkyl, lower alkoxy, lower alkylcarbonyloxy, amino, carboxy, lower alkoxycarbonyl, carboxy(lower alkylene), (lower alkoxy)carbonyl(lower alkylene), lower alkylsulfonyl, lower alkylsulfonylamino, and ureido; R<1> is hydrogen or a substituent selected from the group consisting of hydroxy, halogeno, cyano, nitro, lower alkoxy, amino, carboxy, and lower alkoxycarbonyl; R<2> is hydrogen or lower alkyl; and m is an integer of 1 to 3) or a pharmaceutically acceptable salt of the compound has excellent PDE IV inhibitory activity and is highly safe. They are useful as an antasthmatic and preventive/therapeutic agent for COPD.