| 发明名称 |
SOLID FORMS OF SALTS WITH TYROSINE KINASE ACTIVITY |
| 摘要 |
The present invention relates to solid forms of the hydrochloridesalt3-[5-(4-methanesulfonyl-piperazin-1-ylmethyl)-1H-indol-2-yl]-1H-quinolin-2-one which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angio-genesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals. |
| 申请公布号 |
WO03088900(A3) |
申请公布日期 |
2004.05.21 |
| 申请号 |
WO2003US11022 |
申请日期 |
2003.04.11 |
| 申请人 |
MERCK & CO., INC.;BANYU PHARMACEUTICAL CO., LTD.;KARKI, SHYAM, B.;PAYACK, JOSEPH;TREEMANEEKARN, VARAPORN;WANG, YALING;SATO, YUICHI |
发明人 |
KARKI, SHYAM, B.;PAYACK, JOSEPH;TREEMANEEKARN, VARAPORN;WANG, YALING;SATO, YUICHI |
| 分类号 |
A61K31/138;A61K31/337;A61K31/4465;A61K31/4535;A61K31/454;A61K31/496;A61K38/00;A61K38/21;A61K39/395;A61K45/00;A61P1/04;A61P1/18;A61P3/10;A61P9/00;A61P9/10;A61P11/00;A61P11/04;A61P13/00;A61P15/00;A61P17/00;A61P17/06;A61P19/02;A61P19/08;A61P25/00;A61P27/02;A61P29/00;A61P35/00;A61P35/02;A61P37/08;A61P43/00;C07D401/04 |
主分类号 |
A61K31/138 |
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