HIGH SENSITIVITY MAGNETIC MARKER USED FOR IMMUNE RESPONSE MEASUREMENT

摘要

A high sensitivity magnetic marker preferably used for measurement of an immune response by using a SQUID magnetic sensor and a novel technique about the production are disclosed. A magnetic marker composed of magnetic particl es and polymer coating the surfaces thereof and used for measurement of an immu ne response using a SQUID magnetic sensor. The particle diameter of the magneti c particles (preferably ferrite Fe3O4) is 20 to 40 nm. The outside diameter of the magnetic marker is 40 to 100 nm. The surface of the polymer contains a carboxyl group. The magnetic marker is produced by causing the surfaces of t he magnetic particles to absorb a hydrophilic macromonomer (preferably polyviny l pyrrolydone) having a polymerizable vinyl group and having a molecular weigh t of 500 to 1,000, adding a monomer having a carboxyl group and comprising a hydrophilic vinyl compound and a crosslinking agent, and copolymerizing them .