| 摘要 |
An object of the present invention is to provide an IL-12 expression controlling agent, an inhibitor of IL-12 expression and an enhancer of IL-12 expression for oral administration, which comprise hyaluronan as an active ingredient. The present invention relates to an interleukin-12 expression controlling agent, which comprises hyaluronan as an active ingredient. Specifically, it is an inhibitor of interleukin-12 expression, which comprises hyaluronan or the pharmaceutically acceptable salt thereof having a weight average molecular weight of from 600,000 to 3,000,000 as an active ingredient, or an enhancer of interleukin-12 expression for oral administration, which comprise hyaluronan or the pharmaceutically acceptable salt thereof having a weight average molecular weight of from 50,000 to 400,000 as an active ingredient.
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