| 摘要 |
FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to new derivatives of amines or amides of the general formula (A): wherein R1 means hydrogen atom, hydroxy-group, halogen atom, C1-8-alkyl, C1-8-alkoxy-group, trifluoro-alkyl, C1-8-alkylthio-group; n = 1-2; B1 and B2 mean hydrogen atom; either B1 and B2 represent methylene and taken in common they form six-membered ring; or one of B1 and B2 represents hydrogen atom while the second represents methylene and taken in common they form five-membered ring; m = 0-3; R2 means hydrogen atom, hydroxy-group, C1-6-alkyl, C2-6-alkenyl, halogen atom, C3-7-cycloalkyl, phenyl and others; L means C1-8-alkylene, C2-10-alkenylene, C2-10-alkynylene, C3-7cycloalkylene and others; Y means methylene or carbonyl; Z means aryl, N-sulfoneamido-group, arylamido-group, arylureido-group and others; R3 means C1-6-alkyl, cycloalkyl, naphthyl, heteroaryl and others; R4 means hydrogen atom, C1-8-alkyl, C1-8- alkoxy-group, hydroxy-group, halogen atom, cyano-group and others; R5 means hydrogen atom, C1-8-alkyl, C1-8-alkylcarbonyl, aroyl, carbamoyl and others; R6 means hydrogen atom or C1-8-alkyl; p and q = 1-3. Compounds of the formula (A) represent ligands for receptor Y5 of neuropeptide NPY and can be used in medicine for treatment of disturbances in central nervous system. EFFECT: valuable medicinal properties of compounds. 15 cl, 2 tbl, 14 ex |
