METHOD OF SCREENING SUBSTANCE WHICH CONTROL CELL GROWTH AND METHOD OF SCREENING SUBSTANCE WHICH DISSOCIATE SP1 MOLECULE ETC. FROM NUCLEOLIN MOLECULE

摘要

PROBLEM TO BE SOLVED: To provide medically and industrially useful methods and substances by analyzing in detail the mechanism of DNA synthesis inhibition by S100C. SOLUTION: The medically and industrially useful methods and substances are based on knowledge acquired as the results of analysis on the function of S100C and include a method of screening a substance which dissociates Sp1 molecules from Nucleolin molecules; an Sp1 molecule activating method; an Sp1 molecule activator; a method of screening a substance which inhibits cell growth; a cell growth accelerator; a cell growth inhibitor; and a treatment method of cell proliferative diseases and its curative medicine. It is possible to use the screening methods of this invention etc. for the development of medicines, and they are medically and industrially useful. COPYRIGHT: (C)2004,JPO