| 摘要 |
<p>Fused-polycyclic compounds represented by the general formula [I] and being useful as phosphodiesterase 4 inhibitors, or pharmacologically acceptable salts thereof; and pharmaceutical compositions containing the compounds or the salts: [I] wherein R1 and R2 may be the same or different from each other and are each OH or lower alkoxy; and when A0 is a group represented by the general formula [II], A is a substituted or unsubstituted benzene ring or a substituted or unsubstituted aromatic heterocycle, while when A0 is a group represented by the general formula [III], A is a group represented by the general formula [IV]: [II] [III] [IV] (wherein n is an integer of 1 to 6; when A is a substituted benzene ring or a substituted or unsubstituted aromatic heterocycle, R3 is H or the like, while when A is an unsubstituted benzene ring, R3 is -(CH2)m-R31 or -CO-R32; R31 is H or the like; R32 is aryl or the like; m is an integer of 1 to 6; Q is a free valency attached to A; and Ra and Rb are each independently H or acyl).</p> |
