Treatment and prevention of ebv infection and ebv-associated disorders

摘要

The present invention provides substances suitable for use as vaccines for the prevention of EBV infection and EBV-associated disorders and methods for administering them. The vaccines are directed against HERV-K18 emv (SEQ ID:1) and most preferably comprise antigens obtained from HERV-K18 emv. Preferred antigens include SEQ ID:2, SEQ ID:3 and SEQ ID:4. Most preferably, the SAg T cell stimulatory activity of the HERV-K18 emv is diminished or eliminated. In another embodiment, the vaccine contains a nucleic acid encoding HERV-K18 emv or an immunogenic fragment thereof. The present invention also provides methods for treating EBV infection and EBV-associated disorders.