发明名称 |
Programmable one-pot oligosaccharide synthesis |
摘要 |
The reactivity of a number of p-methylphenyl thioglycoside (STol) donors which are either fully protected or have one hydroxyl group exposed has been quantitatively determined by HPLC in conjunction with the development of a broadly applicable approach for a facile one-pot synthesis of oligosaccharides. The influence on reactivity of the structural effects of different monosaccharide cores and different protecting groups on each glycoside donor is characterized and quantified. In addition, a correlation between glycosyl donor reactivity and the chemical shift of the anomeric proton by <1>H NMR has been established. A database of thioglycosides as glycosyl donors has been created using this reactivity data. The utility is demonstrated by the easy and rapid one-pot assembly of various linear and branched oligosaccharide structures. In addition, a computer program as been described for use as a database search tool and guide for the selection of building blocks for the one-pot assembly of a desired oligosaccharide or a library of individual oligosaccharides. |
申请公布号 |
AU773115(B2) |
申请公布日期 |
2004.05.20 |
申请号 |
AU19990056720 |
申请日期 |
1999.08.10 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
CHI-HUEY WONG;ZHIYUAN ZHANG;IAN OLLMANN;TIMOR BAASOV;XIN-SHAN YE |
分类号 |
C07H1/00;C07H3/06;C08B37/00;G06F17/30;(IPC1-7):C07H1/00 |
主分类号 |
C07H1/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|