| 摘要 |
This invention provides an isolated ABCA1 protein having a mutation within its PEST domain. This invention also provides related nucleic acids, vectors, host cells, pharmaceutical compositions and articles of manufacture. This invention further provides methods for determining whether a protease inhibitor increases the rate of cholesterol efflux from a cell, for increasing ABCA1-mediated cholesterol efflux from a cell, for treating atherosclerosis in a subject, and for increasing HDL formation in a subject.
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