| 摘要 |
PROBLEM TO BE SOLVED: To develop a crosslinked polymer carrier for solid-phsae synthesis, which has functional groups accessible without its high swelling. SOLUTION: The crosslinked polymer, when: (i) functionalized with a 2-chlorotrityl chloride group; (ii) coupled with Leu to 0.65 mmol/g; and (iii) coupled with Glu(t-Bu); allows coupling of FMOC-Lys(BOC)-OH at an amount of 1.5 equivalents in the presence of 1.5 equivalents of HOBT, 1.5 equivalents of DIEA and 1.5 equivalents of HBTU, to be completed, as determined by the Kaiser test, in no more than 35 minutes. COPYRIGHT: (C)2004,JPO
|
