发明名称 |
Novel nonsteroidal anti-inflammatory substances, compositions and methods for their use |
摘要 |
The present invention relates (a) to new compounds represented by Formula I: wherein M represents a macrolide subunit (macrolide moiety) derived from macrolide possessing the property of accumulation in inflammatory cells, D represents a nonsteroidal subunit (nonsteroidal moiety) derived from nonsteroid drug with anti-inflammatory, analgesic and/or antipyretic activity (NSAID) and L represents a linking group covalently linking M and D; (b) to their pharmacologically acceptable salts, prodrugs and solvates, (c) to processes and intermediates for their preparation, and (d) to their use in the treatment of inflammatory diseases and conditions in humans and animals.
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申请公布号 |
US2004097434(A1) |
申请公布日期 |
2004.05.20 |
申请号 |
US20030615010 |
申请日期 |
2003.07.07 |
申请人 |
PLIVA PHARMACEUTICAL INDUSTRY, INCORPORATED |
发明人 |
MERCEP MLADEN;MESIC MILAN;TOMASKOVIC LINDA;MARKOVIC STRIBOR |
分类号 |
C07H17/08;A61K31/7048;A61K31/7052;A61P1/04;A61P9/00;A61P9/10;A61P11/00;A61P11/06;A61P11/08;A61P17/00;A61P17/06;A61P17/16;A61P19/02;A61P19/04;A61P19/06;A61P21/00;A61P27/02;A61P29/00;A61P31/04;A61P37/06;C07H17/00;(IPC1-7):A61K31/704 |
主分类号 |
C07H17/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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